Mesotherapy involves the injection of medications and other substances into the mesoderm, the layer of fat and connective tissue beneath the skin.

Invented in France in 1952, today mesotherapy is used for a variety of cosmetic purposes, including cellulite and spot weight reduction, hair loss, scar revision and skin rejuvenation. It may be an attractive alternative to tumescent liposuction for patients wishing to reduce cellulite or lose excess weight.